Types of Benzimidazoles - Anthelmintic Drugs

 


Anthelmintics, also known as antihelminthics, are a class of antiparasitic medications that either shock or kill parasitic worms (helminths) and other internal parasites without inflicting considerable harm to the host. They are also known as vermifuges (those that stun) or vermicides (those that kill vermin) (those that kill). Anthelmintics are medications that are used to treat helminth infections, also known as helminthiasis. These medications are also utilized in the treatment of diseased animals.

 

In many underdeveloped nations, anthelmintic pills are used in large deworming efforts for school-aged children. Mebendazole and albendazole are the medications of choice for soil-transmitted helminths, while praziquantel is the drug of choice for schistosomiasis and tapeworms.

 

Centurion Healthcare is one of the most popular Anthelmintic drugs exporters in India.

 

Ascaricides are antiparasitics that specifically target worms of the genus Ascaris.

Benzimidazoles:

Benzimidazole is an aromatic heterocyclic chemical molecule. This bicyclic molecule is formed via the reaction of benzene with imidazole. It is solid with no colour.

 

Condensation of o-phenylenediamine with formic acid or the corresponding trimethyl orthoformate yields benzimidazole:

 

C6H4(NH2)2 + HC(OCH3)3 → C6H4N(NH)CH + 3 CH3OH

 

When aldehydes are used instead of formic acid in the condensation, followed by oxidation, 2-substituted derivatives are formed. This procedure yields 2-substituted benzimidazoles.

 

Centurion Healthcare is a noted Anthelmintic drugs supplier in India.

Applications:

Bioactivity is frequently found in benzimidazoles. The benzimidazole class of chemicals includes many anthelmintic medications (Albendazole, Mebendazole, Triclabendazole, Fenbendazole, Triclabendazole, and Flubendazole). Commercialization of benzimidazole fungicides has occurred. They inhibit hyphal growth by attaching to fungal microtubules. It also attaches to spindle microtubules, preventing nuclear division.

●    Albendazole:

Albendazole is a medication used to treat illnesses caused by the tapeworms of dogs and pigs.

 

Albendazole belongs to the class of medications known as anthelmintics. It works by preventing worms from absorbing sugar, causing them to lose energy and perish. It kills threadworms, roundworms, whipworms, tapeworms, and hookworms.

●    Mebendazole:

Mebendazole is a medication that is used to treat several forms of worm diseases. Mebendazole is a medication that is used to treat roundworm and whipworm infections. Mebendazole is a medication used to treat illnesses caused by pinworms, whipworms, roundworms, and hookworms. Mebendazole belongs to the class of drugs known as anthelmintics.

 

Centurion Healthcare is one of the leading Anthelmintic Drugs exporters in Gujarat, India.

●    Thiabendazole:

Thiabendazole is an anti-worm drug known as an "antihelmintic." It inhibits the growth and multiplication of worms in the body.

 

Thiabendazole is used to treat worm illnesses such as threadworm. Thiabendazole can also be used to treat threadworm, pinworm, hookworm, whipworm, roundworm, and trichinosis.

●    Fenbendazole:

Fenbendazole is a benzimidazole anthelmintic that is effective against gastrointestinal parasites such as giardia, roundworms, hookworms, whipworms, the tapeworms genus Taenia (but not Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and Strongyloides. It is effective against a wide range of parasites.

●    Triclabendazole:

Triclabendazole is an antihelminthic medication that was authorized by the FDA in February 2019 for the treatment of fascioliasis in humans. Fascioliasis is a parasitic ailment caused by the helminth Fasciola hepatica, popularly known as "the common liver fluke" or "the sheep liver fluke," or another parasite, Fasciola gigantica. These parasites can infect people once larvae are consumed in polluted water or food. It works well against liver flukes.

●    Flubendazole:

Flubendazole is an anthelmintic medication that veterinarians use to protect dogs and cats from internal parasites and worms. Flubenol, Biovermin, and Flumoxal are some more brand names. It is effective against the vast majority of intestinal parasites.

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